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STAT5 [pY694] Rabbit Polyclonal Antibody
Signal Transducer and Activator of Transcription 5 (STAT5, consists of isoforms a and b) is a ~95 kDa member of a family of transcription factors that are activated to regulate gene transcription in response to multiple hematopoietic cytokines and growth factors. STAT5 is involved in normal cell cycle, survival, and apoptosis, and is implicated in leukaemogenesis and angiogenesis, as it has been found to be constitutively active in many leukemic cell lines. STAT5 activated by phosphorylation of tyrosine 694 in STAT5a (tyrosine 699 in STAT5b), a major Src phosphorylation site that is critical for STAT5 dimerization, translocation and binding to DNA. Phosphorylation of tyrosine 694 is also important in mediating erythropoietin-induced signaling and prolactin-induced development and differentiation of mammary epithelial cells.
Format/Formulation:
Unconjugated
Application:
WB
Reactivity: Mouse
Validated Application: Western Blot
Host: Rabbit
SubClass (Isotype): IgG
Clonality: Polyclonal
Target Gene: STAT5 [pY694]
Gene ID: 6776
Label or Dye: Unconjugated
Target Modification State: Phospho
Product Size: 10 blots
Research Category: Signal Transduction
Other Additives: Sodium Azide Preservative
Shipping Condition: Approved for shipment on Wet or Dry Ice
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.
Store in freezer (-5 to -30°C). |