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LAT [pY132] Rabbit Polyclonal Antibody
This rabbit anti-LAT [pY132] polyclonal antibody is specific to human LAT [pY132]. LAT [pY132] polyclonal antibody recognizes the expressed product of the LAT gene. Tyrosine 132 mediates LAT binding to PLCγ-1, and is necessary for TCR-mediated calcium mobilization and activation of ERK and NFAT proteins. Validated application for LAT [pY132] polyclonal antibody is Western blotting.
Applications: validated for Western blotting
Host species and isotype: rabbit IgG
Reactivity: human LAT [pY132]
Product size: 10 blots pack size
Linker for activation of T cells (LAT) is a 36 kDa transmembrane adapter protein that is tyrosinephosphorylated following T-cell receptor (TCR) stimulation by ZAP-70 and Syk. Four distal tyrosine residues (Y132, Y171, Y191 and Y226 in human LAT) are crucial for its activity and subsequent signaling to downstream molecules. Tyrosine 132 mediates LAT binding to PLCγ-1, and is necessary for TCR-mediated calcium mobilization and activation of ERK and NFAT proteins.
Reactivity: Human
Validated Application: Western Blot
Host: Rabbit
SubClass (Isotype): IgG
Clonality: Polyclonal
Target Gene: LAT [pY132]
Gene ID: 27040
Label or Dye: Unconjugated
Target Modification State: Phospho
Product Size: 10 blots
Purity or Quality Grade: Azide Free
Shipping Condition: Dry Ice
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.
Store in ultra-cold freezer (-68 to -85°C). |