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TTK/Mps1 [pTpS33/37] Polyclonal Antibody, Rabbit
This rabbit anti-TTK/Mps1 [pTpS33/37] polyclonal antibody is specific to human TTK/Mps1 [pTpS33/37]. TTK/Mps1 [pTpS33/37] polyclonal antibody recognizes the expressed product of the TKK gene also known as MPS1. TTK (also known as Mps1; monopolar spindles checkpoint kinase) is a ~97 kDa cell cycle regulated kinase and an essential component of the mitotic spindle checkpoint. Validated applications for TTK/Mps1 [pTpS33/37] polyclonal antibody are Western blotting and immunostaining.
Applications: validated for Western blotting and immunostaining
Host species and isotype: rabbit IgG
Reactivity: human TTK/Mps1 [pTpS33/37]
Product size: 10 blots pack size
TTK (also known as Mps1; monopolar spindles checkpoint kinase ) is a ~97 kDa cell cycle-regulated kinase and an essential component of the mitotic spindle checkpoint. TTK/Mps1 is shown to have maximal activity during M phase and minimal expression in anaphase where it becomes a target of anaphase promoting complex (APC). TTK/hMps1 is a Chk2 kinase where it binds and directly phosphorylates Chk2 kinase at threonine 68. TTK is phosphorylated on several serine and threonine sites including threonines 33 and 360, and serines 37, 362 and 363. Once phosphorylated, TTK/Mps1 is localized to kinetochores where it executes its checkpoint function and regulates multiple cell-cycle related processes, including cell cycle arrest.
Reactivity: Human
Validated Application: Western Blot,
Immunoprecipitation
Host: Rabbit
SubClass (Isotype): IgG
Clonality: Polyclonal
Target Gene: TTK/Mps1 [pTpS33/37]
Gene ID: 7272
Label or Dye: Unconjugated
Target Modification State: Phospho
Purification: Epitope Affinity Purified
Product Size: 10 blots
Shipping Condition: Approved for shipment on Wet or Dry Ice
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.
Store in freezer (-5 to -30°C).
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