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ACC1 Mouse mAb (clone 143)
Acetyl CoA carboxylase (ACC) is a complex multifunctional enzyme system which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA. In cells, excess of metabolic fuel is converted into fatty acids in cytosol and oxidized later in mitochondria to generate ATP and acetyl-CoA. The limiting step in fatty acid synthesis is the catalytic formation of malonyl-CoA (precursor for long-chain fatty acetyl-CoA, LCFA-CoA) from acetyl-CoA by a 256 kDa protein called Acetyl CoA carboxylase 1 (ACC-1).1 The translocation of LCFA-CoA from cytosol to mitochondria is catalyzed by two carnitine palmitoyl transferases (CPT-1 & CPT-2) and regulated by ACC-2, the rate limiting step of mitochondrial fatty acid oxidation. Activities of ACC-1 and 2 are regulated by their phosphorylation by 5’-AMP-activated protein kinase (AMPK).2
Reactivity: Human
Validated Application: Immunoprecipitation,
Western Blot,
ELISA,
Immunofluorescence
Host: Mouse
Clonality: Monoclonal
Clone ID: 143
Target Gene: ACC1
Gene ID: 31
Label or Dye: Unconjugated
Product Size: 100 µg
Research Category: Signal Transduction
Shipping Condition: Wet Ice
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.
Store in freezer (-5 to -30°C). |