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Cathepsin L, Mouse mAb (clone 33/1)
Cathepsin L is a member of the papain superfamily of cysteine proteases in human and mouse and, like many other proteases, it is synthesized as an inactive proenzyme. Cathepsin L is successively translated as pre-procathepsin L, transferred through the Golgi apparatus as procathepsin L and then stored in lysosomes as mature cathepsin L. Cathepsin L is expressed during fetal lung development along with cathepsin B, H, K, and S at protein and mRNA levels.
Isotype: Mouse IgG1
Clone/PAD: 33/1
Immunogen: Purified human procathepsin L from conditioned culture medium of human non-small cell lung cancer EPLC (32M1) cell line.
Specificity: This antibody is specific for human cathepsin L (cathepsin L precursor, MEP) protein (accession # NP_001903.1, P07711), which is 100% identical with chimpanzee and 96% homologous with rhesus monkey.
Reactivity: Reactivity has been confirmed with human recombinant cathepsin L and 32M1 cell lysates using western blotting. The reactivity has been also confirmed with human thyroid carcinoma cell lines (FTC-238) by immunofluorescence.(1) Based on amino acid sequence homology, reactivity with chimpanzee and rhesus monkey is also expected.
Applications: Immunofluorescence, Western Blotting
Reactivity: Human
Validated Application: Immunofluorescence,
Western Blot
Host: Mouse
Clonality: Monoclonal
Clone ID: 33⁄1
Target Gene: CTSL1
Gene ID: 1514
Label or Dye: Unconjugated
Purification: Affinity Purified
Product Size: 100 µg
Shipping Condition: Wet Ice
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.
Store in freezer (-5 to -30°C). |