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Retinoid X Receptor Alpha Mouse anti-Human Monoclonal Antibody (clone K8505)
Retinoid X receptor-α (RXR-α; NR2B1) is a member of the orphan nuclear receptor family. 9-cis retinoic acid can bind to RXR. RXR-α is expressed in liver, muscle, lung, kidney, intestine, heart and spleen. RXR-α plays an important role in a variety of processes including embryonic patterning and organogenesis, cell proliferation and differentiation. RXRs commonly function as heterodimers with other members of the nuclear receptor superfamily.
Isotype
Mouse IgG2a
Clone/PAD
K8505
Immunogen
Produced in BALB/c mouse ascites after inoculation with hybridoma of mouse myeloma cells (NS-1) and spleen cells derived from a BALB/c mouse immunized with Baculovirus-expressed recombinant human RXR-α (2-133 aa).
Specificity
This antibody specifically recognizes human RXRα and cross reacts with mouse and rat RXRα. This antibody does not recognize human RXRβ and γ.
Reactivity
Hu, Ms, Rt
Applications
Western Blot, ELISA, Electrophorectic Mobility Shift Assay, Immunoprecipitation, Chromatin Immunoprecipitation, Immunohistochemistry (WB, E, EMSA, IP, ChIP, IHC)
Store in freezer (-5 to -30°C). |