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Vaccinia-related Kinase 1 (VRK1) Mouse Monoclonal Antibody (clone IF6)
Mouse anti-VRK1. Monoclonal antibody specific to Human VRK1. This antibody is validated for use Western Blot, and Immunoprecipitation. VRK1 is encoded by VRK1 Gene. Mouse anti-VRK1. Monoclonal antibody specific to Human VRK1. This antibody is validated for use Western Blot, and Immunoprecipitation. VRK1 is encoded by VRK1 Gene. Vaccinia-Related Kinase (VRK) proteins are a new family with three members in the human kinome. VRK1 is a serine⁄threonine kinase which phosphorylates transcription factors related to stress responses, such as p53. VRK1 phosphorylates human p53 in threonine 18 leading to its accumulation. VRK1 is also autophosphorylated at various serine and threonine residues. However, this does not impair its ability to phosphorylate p53. There also seems to be an autoregulatory loop between p53 and its stabilizing VRK1 since inverse correlation between VRK1 and p53 levels are observed in several cell lines. VRK1 also phosphorylates c-Jun at serines 63 and 73, inducing the
Reactivity: Human
Validated Application: Western Blot,
Immunoprecipitation
Host: Mouse
CubClass (Isotype): IgG1
Clonality: Monoclonal
Clone ID: IF6
Target Gene: Vaccinia-related kinase 1 (VRK1)
Gene ID: 7443
Gene Symbol: VRK1
Accession Number: NC.000014.7
Gene Aliases: MGC142070,
MGC138280,
MGC117401
Label or Dye: Unconjugated
Purification: Pure
Concentration: 0.5 mg⁄ml
Product Size: 100 µg
Shipping Condition: Wet Ice
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.
Store at -20°C |