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Liver X Receptor Alpha Mouse anti-Human Monoclonal Antibody (clone K8607)
Liver X receptor-α (LXRa, RLD-1; NR1H3) is a member of the orphan nuclear receptor family. LXR-α activator is the naturally occurring compound 22-(R)ƒhydroxycholesterol (22(R)-HC), 20(S)HC, 24-HC, 25ƒHC, 7α-HC. LXR-α is expressed in the liver, kidney and spleen. LXR-α has an important role in regulating cholesterol metabolism. It is believed that LXR specific agonist may have important medical applications in the regulation of cholesterol homeostasis. LXR-α forms a heterodimer with RXR.
Isotype
Mouse IgG2a
Clone/PAD
K8607
Immunogen
Produced in BALB/c mouse ascites after inoculation with hybridoma of mouse myeloma cells (NS-1) and spleen cells derived from a BALB/c mouse immunized with Baculovirus-expressed recombinant human LXR-α (2-97 aa).
Specificty
This antibody specifically recognizes LXRα but does not recognize human LXRβ. Not yet tested in other species.
Reactivity: Human
Validated Application: ELISA,
Western Blot,
Electrophoretic Mobility Shift Assay,
Immunoprecipitation
Host: Mouse
Clonality: Monoclonal
Clone ID: K8607
Target Gene: Liver X Receptor alpha
Gene ID: 22259
Label or Dye: Unconjugated
Product Size: 100 µg
Research Category: Signal Transduction
Shipping Condition: Wet Ice
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.
Store in freezer (-5 to -30°C). |