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PTTG-1 Rabbit Polyclonal Antibody
This rabbit anti-PTTG-1 polyclonal antibody is specific to human PTTG-1. PTTG-1 polyclonal antibody recognizes the expressed product of the PTTG1 gene. Pituitary tumor-transforming gene 1 (PTTG-1) is an oncogene expressed in normal tissues containing proliferating cells and in tumors. Validated applications for PTTG-1 polyclonal antibody are Western blot, immunohistochemistry and ELISA.
Applications: validated for are Western blot, immunohistochemistry and ELISA
Host species and isotype: rabbit IgG
Polyclonal Antibody Designation: Z23.YU
Reactivity: human PTTG-1
Product size: 100 µg pack size
Pituitary tumor-transforming gene 1 (PTTG-1) is an oncogene expressed in normal tissues containing proliferating cells and in tumors. PTTG is downstream of the MAP kinase signaling cascade and is phosphorylated at Ser162 by MAPK in vitro. Phosphorylation plays an essential role in PTTG's transactivation function. The PTTG protein contains a DNA-binding domain, and it activates transcription of the c-Myc oncogene by binding to the promoter to form a complex. Studies have demonstrated that expression of human PTTG correlates with cell proliferation in a cell cycle-dependent manner, and the association of human PTTG with Ku, the regulatory subunit of DNA-dependent protein kinase, is disrupted when a DNA double-strand breaks occurs.
Reactivity: Human
Validated Application: Immunohistochemistry,
Western Blot,
ELISA
Host: Rabbit
SubClass (Isotype): IgG
Clonality: Polyclonal
Target Gene: PTTG-1
Gene ID: 9232
Label or Dye: Unconjugated
Purification: Epitope Affinity Purified
Product Size: 100 µg
Shipping Condition: Wet Ice
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.
Store in freezer (-5 to -30°C). |