c-Met Mouse Monoclonal Antibody (clone 3D4), Concentrate This antibody reacts specifically with c-Met protein. The c-Met protein is a receptor tyrosine kinase encoded by the c-Met proto-oncogene. Deregulated c-Met expression has been detected at both protein and mRNA levels in a variety of human carcinomas and sarcomas. Antibodies against the intracellular but not the extracelluar domain of c-Met reportedly give prognostic information, suggesting that overexpression of the cytoplasmic tail of c-Met may play an important role in breast cancer progression. Immunogen source: Synthetic peptide derived from cytoplasmic domain of human c-Met protein. Positive tissue: Breast carcinoma. Reactivity: Human Validated Application: Immunohistochemistry (FFPE) Host: Mouse SubClass (Isotype): IgG2a Clonality: Monoclonal Target Gene: c-Met Gene ID: 4233 Label or Dye: Unconjugated Dilution: Concentrate Antibody Product Size: 0.5 mL Shipping Condition: Wet Ice Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures. Store in refrigerator (2–8°C).