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Transferrin Receptor Mouse mAb (H68.4)
This purified monoclonal mouse IgG1 antibody recognizes transferrin receptor.
Antibody Specifications:
• Validated in: Western Blot, Immunoprecipitation, Immunohistochemistry (paraffin), ELISA, Immunofluorescence
• Isotype: Mouse IgG1
• Clone: H68.4
• Reactivity: Human, Mouse, Rat, Chinese Hamster, Chicken
• Volume: 200 µl (0.5 mg/ml)
• Buffer: Phosphate buffered saline containing 0.1% sodium azide
The human transferrin receptor (TfR) is a homodimeric type II membrane protein consisting of two identical 95 kDa subunits covalently linked by intermolecular disulfide bonds. The TfR has an extracellular domain of 671 amino acids, a single 28 residue transmembrane region and a 61 residue amino terminal cytoplasmic domain. Expression of the receptor is limited on normal tissue, however, highly expressed on the surface of some tumors. TfR is included in the class of ligand transport receptors which are internalized and clustered in coated pits. An important function of the receptor is to bind the serum transport protein transferrin (Tf) and mediate the uptake of iron into the cell. A growing area of research involves the use of monoclonal anti-TF receptor antibodies to inhibit the uptake of iron and thus block tumor cell growth.
Reactivity: Rat,
Hamster,
Mouse,
Chicken
Validated Application: ELISA,
Immunohistochemistry (FFPE),
Western Blot,
Electron Microscopy,
Flow Cytometry,
Immunoprecipitation,
Immunofluorescence
Host: Mouse
Clonality: Monoclonal
Clone ID: H68.4
Target Gene: Transferrin Receptor
Gene ID: 7037
Label or Dye: Unconjugated
Purification: Affinity Purified
Product Size: 100 µg
Shipping Condition: Wet Ice
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.
Store in freezer (-5 to -30°C). |