MSH6 Mouse Antibody (clone 44), 2ndGen Predilute This antibody reacts specifically with MSH6 protein. The human Mut-S-homologue-6 (hMSH-6) gene product is a member of a highly conserved family of proteins. MSH6 is localized to the cell nucleus. Eukaryotic MLH and MSH proteins are involved in DNA mismatch repair and recombination pathways. This function is only active when MSH6 is heterodimerized with MSH2. Defects in mismatch repair systems cause elevated spontaneous mutation rates and increased instability of DNA microsatelite repetitive sequences expressed (MSI). Mutations in the human genes are associated with hereditary nonpolyposis colon cancer (HNPCC). Immunogen source: Fusion protein derived from human muscle. Positive tissue: Colon cancer. Clone/PAD: 44 Reactivity: Human Reactivity: Human Validated Application: Immunohistochemistry (FFPE) Host: Mouse Target Gene: MSH6 Gene ID: 2956 Label or Dye: Unconjugated Dilution: 2ndGen Predilute Antibody Product Size: 6 mL Shipping Condition: Wet Ice Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures. Store in refrigerator (2–8°C).