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E-Cadherin Mouse Monoclonal Antibody (clone 4A2C7), 2ndGen Predilute
This monoclonal antibody reacts with human epithelial cadherin (E-cadherin, uvomorulin, Cell-CAM 120/80), a 120 kDa transmembrane glycoprotein. Reduction and/or loss of E-cadherin expression in carcinomas correlates positively with tumor cell invasion and metastasis. Altered expression of E-cadherin is common in the progression of cancers including breast carcinoma, lung carcinoma, gastric tumors, hepatocellular carcinoma, and prostatic tumors. It has recently been reported that E-cadherin is a useful marker for differentiating lobular lesions (negative) from ductal invasive lesions (positive) in breast cancer. Positive tissue: Non-neural epithelia.
Clone/PAD: 4A2C7
Immunogen: Recombinant protein corresponding to the cytoplasmic domain of human E-cadherin
Specificity: Reacts strongly with human E-cadherin and weakly with human P-cadherin.
Reactivity: Human
Applications: Immunohistochemistry (FFPE)
Pretreatment: Epitope Retrieval: Required (Citrate Buffer, pH 6), Enzyme Digestion: Not required
Expected Staining Pattern: Mainly cellular membrane, some cytoplasmic
Reactivity: Human
Validated Application: Immunohistochemistry (FFPE)
Host: Mouse
Target Gene: E-Cadherin
Gene ID: 999
Label or Dye: Unconjugated
Dilution: 2ndGen Predilute Antibody
Product Size: 6 mL
Shipping Condition: Wet Ice
Regulatory Statement: For In Vitro Diagnostic Use.
Store in refrigerator (2–8°C).
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