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Fibronectin, Bovine
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PRODUCT FAMILY INFORMATION
Fibronectin Antibodies, Proteins & Assays
Millipore’s Fibronectin Antibodies, proteins, and assays are based on the expertise of Upstate & Chemicon. See below products related to Fibronectin research, including Migration assays & ELISA kit.
EMD Millipore’s Fibronectin related Antibodies, proteins and assays are based on the expertise of Upstate & Chemicon. All have been well validated and published. See below for data, references and related products for Fibronectin.
ECM Proteins and Coated Plates
Meet cell type-specific needs for growth and adhesion
Millipore offers a wide variety of ECM proteins and coated cultureware to meet the individual needs of your cell line. Our ECM Cell Culture Optimization Array can help you determine the best coating and concentration for your particular cell type.
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Description:
Fibronectin, Bovine
Trade Name:
Chemicon (Millipore)
Qty/Pk:
500 µg
Product Overview:
Bovine fibronectin was purified from bovine plasma over a gelatin agarose column. A single band at 220kDa (reduced) is identified, corresponding to intact fibronectin under reduced conditions.
Key Applications:
Cell Culture
Application Notes:
ELISA, Ouchterlony and immunoblotting.
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Entrez Gene Summary:
This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined.
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UniProt Summary:
FUNCTION: SwissProt: P02751 # Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Interaction with TNR mediates inhibition of cell adhesion and neurite outgrowth (By similarity).
SIZE: 2386 amino acids; 262607 Da
SUBUNIT: Mostly heterodimers or multimers of alternatively spliced variants, connected by 2 disulfide bonds near the carboxyl ends; to a lesser extent homodimers. Interacts with FBLN1, AMBP, TNR, LGALS3BP and COL13A1.
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
TISSUE SPECIFICITY: Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix. Ugl-Y1, Ugl-Y2 and Ugl-Y3 are found in urine.DEVELOPMENTAL STAGE: Ugl-Y1, Ugl-Y2 and Ugl-Y3 are present in the urine from 0 to 17 years of age.
PTM: Sulfated.
SIMILARITY: SwissProt: P02751 ## Contains 12 fibronectin type-I domains. & Contains 2 fibronectin type-II domains. & Contains 16 fibronectin type-III domains.
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Species:
Bovine
Brand Family:
Chemicon
Source:
Bovine plasma
Presentation:
Liquid in a solution of 2M Urea in 0.05 M Tris p |