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Human Amylin ELISA
Description:
Human Amylin ELISA
Qty/Pk:
96-well plate
Background Information:
Amylin is a 37 amino acid hormone that is co-secreted with insulin from pancreatic beta cells in response to hyperglycemia.
Applications:
This Human Amylin ELISA is used to measure & quantify Amylin levels in Metabolism & Endocrine research.
Key Applications:
ELISA
Application Notes:
50 μl plasma or cell culture supernatant 3.5 hour protocol, room temperature
Species Reactivity:
Human
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Entrez Gene Summary:
Islet, or insulinoma, amyloid polypeptide (IAPP, or amylin) is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. While the assosciation of amylin with the development of type II diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Recent results suggest that amylin, like the related beta-amyloid (Abeta) assosciated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes.
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UniProt Summary:
FUNCTION: SwissProt: P10997 # Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
SIZE: 89 amino acids; 9806 Da
SUBCELLULAR LOCATION: Secreted.
DISEASE:SwissProt: P10997 # IAPP is the peptide subunit of amyloid found in pancreatic islets of type 2 diabetic patients and in insulinomas.
SIMILARITY: SwissProt: P10997 ## Belongs to the calcitonin family.
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Gene Symbol:
IAPP
AMYLIN
IAP
Amylin
DAP
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Cross Reactivity:
This kit will be suitable for the measurement of amylin in rat and feline plasma, however, the precise percent of cross-reactivity is not determined.
Product Name:
Human Amylin ELISA
Standard Curve Range:
1–100 pM
Analytes Available:
Amylin
UniProt Number:
P10997
Precision, %:
Inter-assay: 5.2–1.3
Intra-assay: 1.9 ± 0.7
Accuracy:
96 ± 2.5%
Detection Methods:
Fluorescent
Colorimetric
Entrez Gene Number:
NM_000415.1 |