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αVβ3 Integrin Investigator Kit
Description:
αVβ3 Integrin Investigator Kit
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Trade Name:
Chemicon (Millipore)
Product Overview:
Chemicon Investigator Kits for Integrin Research are a cost-effective source of reagents for investigators involved with the rapidly expanding field of integrin research. The alphaVbeta3 Investigator kit is designed for research focused on the alphaVbeta3 integrin.
Integrins belong to a large family of cell surface proteins commonly referred to as glycoproteins. Integrins are composed of noncovalently associated alpha and beta subunits which make up heterodimers: the larger termed alpha chain and the smaller beta chain. At least 16 alpha subunits and 8 beta subunits are expressed, which can give rise to 22 different integrins. Integrins are thought to play critical roles in cell migration, differentiation, and survival. There is now considerable evidence that these transmembrane receptors play an important role in the regulation of gene expression and signal transduction. Excellent reviews of integrin structure, function, and ligand specificity may be found in: Hynes, R. 1992. Cell 69:11-25; Kramer, R. 1993. "Integrin Structure and Ligand Specificity in Cell-Matrix Interactions" in Molecular and Cellular Aspects of Basement Membranes. Academic Press.
The significance of integrin alphaVbeta 3 as a marker of angiogenesis has been discussed in great detail. Addition of the monoclonal antibody, LM609, is known to block the interaction of the alphaVbeta 3 molecule with its ligands vitronectin, fibrinogen, von Willibrand factor, and CD31/PECAM-1. [Cheresh, D.A., PNAS USA 84: 6471-75].
Chemicon offers the Integrin alphaVbeta 3 Investigator Kit for initial studies of alphaVbeta 3 interactions. All kit reagents are also available in larger catalog or in bulk sizes. The reagents in this kit are not application specific but rather may be used in a variety of procedures, depending upon the needs of the individual investigator.
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Species Reactivity:
Human
Mouse
Presentation:
The alphaVbeta3 Integrin Investigator Kit contains antibodies to alphaVbeta3 (20 μg), alphaV (20 μL), beta3 (20 μL), and purified functionally active alphaVbeta3 protein (10 μg).
Storage Conditions:
Antibodies in kit should be stored at -20°C.
Purified alphaVbeta3 protein must be stored at -70°C.
Important Note: Due to the small volumes contained within the kit, we recommend gently tapping the vials on a hard surface before opening or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid entrapped in the container's cap during shipment.
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UniProt Number:
P06756
Entrez Gene Number:
NM_002210.2
Gene Symbol:
ITGAV
CD51
DKFZp686A08142
VNRA
MSK8
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Components:
alphaV Rabbit Polyclonal Antibody (Part No. AB1930-20) - 1 tube, 20 μL.
beta3 Rabbit Polyclonal Antibody (Part No. AB1932-20) - 1 tube, 20 μL.
alphaVbeta3 Mouse Monoclonal Antibody (Part No. MAB1976Z-20) - 1 tube, 20 μg. Note: This antibody does not work on mouse
alphaVbeta3 Purified Integrin Protein (Part No. CC1018-10 ) - 1 tube, 10 μg.
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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