|
Human sICAM-1 ELISA
Close
PRODUCT FAMILY INFORMATION
ICAM Antibodies & Kits
Millipore’s ICAM Antibodies demonstrate specificity against ICAM or CD54, an adhesion molecule in immune cells. See below for related products for ICAM, based on the expertise of Upstate & Chemicon.
Millipore’s Anti- ICAM Antibodies demonstrates specificity against ICAM. See below for data, references and related products for ICAM. All Millipore antibodies are based on the expertise of Upstate & Chemicon.
» More…
Acute Injury and Chronic Neurodegeneration Antibodies, Immunoassays, & Histological Stains
Millipore offers a range of products for neurodegeneration research: detection & staining of dying neurons. See below for products for products based on the expertise of Upstate & Chemicon.
A general feature of many neurological diseases, disorders, or injuries is the degeneration of proximal and/or distal neural processes. Key to understanding the degenerative progression is detecting and staining these dying neurons. EMD-Millipore has developed several methods for detecting neurodegeneration in blood/CSF samples and tissue sections. Several ELISA based assays are now available for neurodegenerative biomarkers, including phosphoNF-H, GFAP, and alpha synuculein. In addtion, Millipore’s non-antibody based tissue section stains for various stages of degenerating neurons are very robust regardless of specific insult or mechanism of cell death.
» More…
Description:
Human sICAM-1 ELISA
Trade Name:
Chemicon (Millipore)
Qty/Pk:
1 kit
Product Overview:
Intercellular Adhesion Molecule-1 (ICAM-1) is a member of the immunoglobulin supergene family [Rothlein et al., 1988] and functions as a ligand for integrin alphaLbeta2 or Lymphocyte Function-Associated Antigen-1 (LFA-1), a member of the leukocyte integrin family [Marin & Springer 1987] which mediates lymphocyte adhesion.
ICAM-1 is a single-chain glycoprotein with a polypeptide core of 55kDa expressed on non-hematopoietic cells of many lineages including vascular endothelial cells, thymic epithelial cells, other epithelial cells and fibroblasts, and on hematopoietic cells such as tissue macrophages, mitogen-stimulated T-lymphoblasts, germinal center B-cells and the dendritic cells from tonsils, lymph nodes and Peyer's patches. ICAM-1 is inducible on fibroblasts and endothelial cells by the inflammatory mediators IL-1, TNF and IFN-gamma. Its presence correlates with infiltration of lymphocytes into inflammatory lesions [Dustin et al., 1989; Prober et al., 1986; Rothlein et al., 1986]. ICAM-1 seems to be the initial marker of inflammatory reactions and is expressed prior to and to a greater extent than HLA-DR.
The role of ICAM-1 as a disease marker has been demonstrated for a number of different pathologies, including allergic rhinitis, allergic contact dermatitis [Vejlsgaard et al. 1989], gastrointestinal and bladder cancer, lymphoproliferative disorders [Lal et al., 1992; Rothlein et al., 1991], melanoma [Altomone et al., 1992; Becker et al., 1992; harning et al., 1991], HIV-1 infection [Most et al., 1993], malaria, tissue or organ transplant rejection [Adams et al., 1989; Adams et al., 1993], diabetes mellitus [Lampeter et al., 1992], glomerulonephritis, asthma [Wegner et al., 1990], rheumatoid arthritis [Popocnik et al., 1990] and psoriasis [Lisby et al., 1989].
A panel of 50 sera from healthy blood donors (male and female) was tested for sICAM-1. The detected sICAM levels ranged between 129.9 and 297.4 ng/ml with a mean of 230.3 ng/ml and a standard deviation of 47.4 ng/ml. Normal sICAM-1 levels may vary depending on the serum collective used ranging up to 400ng/ml or greater. Depending upon the study population ranges from 219ng/ml to 1050ng/ml have been reported in the literature.
|