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QCM 3 μm Endothelial Cell Migration Assay - Fibronectin, Fluorometric
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PRODUCT FAMILY INFORMATION
Fibronectin Antibodies, Proteins & Assays
Millipore’s Fibronectin Antibodies, proteins, and assays are based on the expertise of Upstate & Chemicon. See below products related to Fibronectin research, including Migration assays & ELISA kit.
EMD Millipore’s Fibronectin related Antibodies, proteins and assays are based on the expertise of Upstate & Chemicon. All have been well validated and published. See below for data, references and related products for Fibronectin.
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Cell Based Assays
Millipore offers a significant portfolio of well-published, quantitative and optimized live cell, whole-cell, and cell-based activity assays. Study Apoptosis, Angiogensis, Adhesion and more.
EMD Millipore offers a significant portfolio of well-published, quantitative and optimized live cell, whole-cell and cell-based activity assays that mimic native environments for direct and indirect detection of cellular response.
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Description:
QCM 3 μm Endothelial Cell Migration Assay - Fibronectin, Fluorometric
Trade Name:
QCM
Chemicon (Millipore)
Qty/Pk:
1 kit
Product Overview:
Also available: Cell Comb™ Scratch Assay! Get biochemical data from a scratch assay! Click Here)
Introduction
Angiogenesis is a fundamental process involving the growth of new blood vessels from pre-existing vessels. It is important in development and wound healing, as well as pathologic diseases such as diabetic retinopathy and cancer. During angiogenesis, endothelial cells need to move out of existing vessels, migrate into new areas, proliferate and assemble into new capillaries. The migration of endothelial cells is regulated by many angiogenic factors and anti-angiogenic factors. It is critical for researchers to understand the mechanisms of endothelial cell migration.
Millipore's 3 μm QCM™ Endothelial Cell Migration Assay – Fibronectin, Fluorometric provides a quick and efficient system to study the ability of compounds to induce or inhibit endothelial cell migration. This assay also allows screening of pharmacological agents, evaluation of integrins or other adhesion receptors responsible for endothelial cell migration, analysis of gene function in transfected cells, and determination of ECM protein involvement in cell movement.
This versatile assay permits counting of individual migratory cells, and, more importantly, allows quantitative analysis by optical density (OD) using a standard microplate reader. This convenient assay allows large scale screening and quantitative comparison of multiple samples and includes individual migration controls for each sample.
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Applications:
This QCM 3 μm Endothelial Cell Migration Assay – Fibronectin, Fluorometric is ideal for the study of endothelial cell migration in response to an angiogenic stimulus.
Application Notes:
The Millipore QCM™ 3 μm Endothelial Cell Migration Assay – Fibronectin, Fluorometric is ideal for the study of endothelial cell migration in response to an angiogenic stimulus. The quantitative nature of this assay is especially useful for large scale screening of pharmacologic agents. BSA-coated control chambers provide an appropriate migration control. The 3 μm pore size in this assay is optimal for endothelial cells such as HUVEC, but not sufficient for fibroblast migration. The Millipore QCM™ 3 μm Endothelial Cell Migration Assay – Fibronectin, Fluorometric assay is intended for research use only; not for diagnostic applications.
Each kit provides sufficient materials for the evaluation of 12 samples.
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Species Reactivity:
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