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PI3 Kinase Activity/Inhibitor ELISA
Description:
PI3 Kinase Activity/Inhibitor ELISA
Qty/Pk:
1 plate
Applications:
This PI3 Kinase Activity/Inhibitor ELISA is used to measure & quantify PI 3-Kinase levels.
Key Applications:
Kinase Assay
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Entrez Gene Summary:
Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers.
UniProt Summary:
FUNCTION: SwissProt: P42336 # Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2.
SIZE: 1068 amino acids; 124284 Da
SUBUNIT: Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit. Binds to IRS1 in nuclear extracts. Interacts with RUFY3 (By similarity).
DISEASE: SwissProt: P42336 # Defects in PIK3CA are associated with colorectal cancer (CRC) [MIM:114500]. & Defects in PIK3CA are associated with breast cancer [MIM:114480]. & Defects in PIK3CA are associated with epithelial ovarian cancer (EOC) [MIM:604370].
SIMILARITY: SwissProt: P42336 ## Belongs to the PI3/PI4-kinase family. & Contains 1 C2 domain. & Contains 1 PI3K/PI4K domain.
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Gene Symbol:
p110-alpha
MGC142161
PI3K
MGC142163
PIK3CA
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Product Name:
PI3 Kinase Activity/Inhibitor ELISA
Analytes Available:
PI 3-Kinase
Components:
Glutathione-Coated Plate, 96-well strip format
20% Tween® 20
20X TBS Wash
Substrate TMB
Stop Buffer
SA-HRP Detection Reagent
GRP1-GST
Kinase Reaction Buffer, 5X
Wortmannin
PIP2
Biotinylated-PIP3
PI3K, p110α
PI3K, p110β
PI3K, p110δ
PI3K, p120γ
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UniProt Number:
P42336
Detection Methods:
Colorimetric
HTRF
Packaging:
Kit capacity: 96 wells
Entrez Gene Number:
NM_006218.2 |