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Acetyl-Histone H4 Antibody Set
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REFERENCES
Molecular mechanism underlying the differential MYF6 expression in postnatal skeletal muscle of Duroc and Pietrain breeds.
(2011) Gene.486:8-14
A component of BRAF-HDAC complex, BHC80, is required for neonatal survival in mice.
Shigeki Iwase, Naomi Shono, Arata Honda, Tomoko Nakanishi, Shin-ichi Kashiwabara, Satoru Takahashi, Tadashi Baba (2006) FEBS letters.580:3129-35
Species Reactivity Key Applications Host Format Antibody Type
H, M, R, B, Po, Rb, Yeast (S. cerevisiae) WB, ICC Rabbit null null
Description:
Acetyl-Histone H4 Antibody Set
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Trade Name:
Upstate (Millipore)
Modifications:
Acetylation
Species Reactivity:
Human
Mouse
Rat
Bovine
Pig
Rabbit
Yeast (S. cerevisiae)
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Quality Assurance:
routinely tested by immunoblot analysis on acid extracts of HeLa cells treated with sodium butyrate.
UniProt Number:
P62805
Entrez Gene Number:
NM_003538.3
Gene Symbol:
HIST1H4A
H4/J
HIST1H4F
HIST1H4L
H4FN
H4FA
H4FH
HIST1H4H
H4F2
H4FM
H4/A
H4FK
H4FG
HIST2H4
H4FB
H4/K
HIST1H4I
H4/N
HIST1H4B
H4FE
H4/M
H4/a
HIST1H4E
HIST4H4
HIST2H4A
H4FC
H4FI
H4/H
HIST1H4C
H4/G
HIST1H4K
H4FJ
H4FD
H4/I
H4/B
H4/D
H4/C
HIST1H4J
HIST1H4D
H4/E
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Components:
Anti-Acetyl-Histone H4 (Lys5)
Anti-Acetyl-Histone H4 (Lys 8)
Anti-Acetyl-Histone H4 (Lys 12)
Anti-Acetyl-Histone H4 (Lys 16)
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Immunocytochemistry
Entrez Gene Summary:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.
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UniProt Summary:
FUNCTION: SwissProt: P62805 # Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
SIZE: 103 amino acids; 11367 Da
SUBUNIT: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H |