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Tyrosine Kinase (Src Family) Substrate Peptide Pack, 1 kit
Description:
Tyrosine Kinase (Src Family) Substrate Peptide Pack
Trade Name:
Upstate (Millipore)
Qty/Pk:
1 kit
Product Overview:
Src-family kinases tested:
v-Src, c-Src, c-Yes, Lck, Lyn and Fyn
Non-Src kinases tested:
EGF receptor, insulin receptor, Syk, and Abl
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Applications:
Peptide pack of Tyrosine Kinase (Src Family) Substrate use in Kinase Assays.
Key Applications:
Kinase Assay
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Entrez Gene Summary:
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
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UniProt Summary:
SIZE: 536 amino acids; 59835 Da
SUBUNIT: Interacts with DDEF1/ASAP1 via its SH3 domain. Interacts with CCPG1 (By similarity). Interacts with CDCP1, PELP1, TGFB1I1 and TOM1L2.
PTM: Phosphorylated on Tyr-530 by c-Src kinase (CSK). The phosphorylated form is termed pp60c-src. The phosphorylated tail interacts with the SH2 domain thereby repressing kinase activity.
SIMILARITY: SwissProt: P12931 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain.
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Brand Family:
Upstate
Gene Symbol:
SRC
ASV
c-src
p60-Src
SRC1
c-SRC
pp60c-src
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Product Name:
Tyrosine Kinase (Src Family) Substrate Peptide Pack
Quality Assurance:
Routinely evaluated by assaying for Src-family protein tyrosine kinases in cell and tissue extracts and immunoprecipitates
Components:
[Lys19] cdc2 (6-20)-NH2
[Lys19, Phe15] cdc2 (6-20)-NH2
[Lys19, Ser14, Val12] cdc2 (6-20)-NH2
UniProt Number:
P12931
Entrez Gene Number:
NM_005417.3
NM_198291.1 |