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Anti-O-GlcNAc, clone 9D1.E4(10)
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REFERENCES
Antibodies that Detect O-GlcNAc on the Extracellular Domain of Cell Surface Glycoproteins.
Tashima, Yuko and Stanley, Pamela (2014) J. Biol. Chem., (2014)
Glucose Deprivation-induced Increase in Protein O-GlcNAcylation in Cardiomyocytes Is Calcium-dependent.
Luyun Zou,Xiaoyuan Zhu-Mauldin,Richard B Marchase,Andrew J Paterson,Jian Liu,Qinglin Yang,John C Chatham (2012) The Journal of biological chemistry.287
Glycopeptide-specific monoclonal antibodies suggest new roles for O-GlcNAc.
Teo, Chin Fen, et al. (2010) Nat. Chem. Biol., 6: 338-43 (2010)
Species Reactivity Key Applications Host Format Antibody Type
H WB Mouse Purified Monoclonal Antibody
Description:
Anti-O-GlcNAc Antibody, clone 9D1.E4(10)
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Specificity:
This antibody recognizes O-GlcNAc.
Molecular Weight:
Various
Immunogen:
SANM-conjugated linear peptide corresponding to human O-GlcNAc.
Clone:
9D1.E4(10)
Isotype:
IgG1
Background Information:
O-linked N-acetylglucosamine (O-GlcNAc), is a member of the O-GlcNAc transferase family. O-GlcNAc is a posttranslational modification characterized by the attachment of N-acetylglucosamine to specific serine/threonine hydroxyl groups. It plays an important role in nutrient sensing, gene expression, and protein degradation. O-GlcNAc is widely expressed in the pancreas and is present in smaller amounts in skeletal muscle, heart, brain and placenta.
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Species Reactivity:
Human
Species Reactivity Note:
Proven to react with human.
Control:
HEK293 cell lysate
Quality Assurance:
Evaluated by Western Blot in O-GlcNAc transferease transfected HEK293 cell lysate and O-GlcNAcase transfected transfected HEK293 cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected O-GlcNAc on 10 µg of
O-GlcNAc transferease transfected HEK293 cell lysate and O-GlcNAcase transfected transfected HEK293 cell lysate.
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Purification Method:
Protein G purfied
Presentation:
Purified mouse monoclonal antibody in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% sodium azide.
Storage Conditions:
Maintain refrigerated at 2-8°C for up to 12 months.
UniProt Number:
O15294
Entrez Gene Number:
NP_858058.1
Gene Symbol:
EC 2.4.1
FLJ23071
HRNT1
MGC22921
O-GLCNAC
OTTHUMP00000032154
OTTHUMP00000032166
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Alternate Names:
O-GlcNAc transferase p110 subunit
O-GlcNAc transferase subunit p110
O-linked GlcNAc transferase
O-linked N-acetylglucosamine (GlcNAc) transferase
(UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase
O-linked N-acetylglucosamine transferase 110 kDa subunit
uridinediphospho-N-acetylglucosamine:polypeptide
beta-N-acetylglucosaminyl transferase
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Entrez Gene Summary:
O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT) catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine re |