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Anti-IL-1R1 Antibody, rabbit monoclonal
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REFERENCES
MyD88: an adapter that recruits IRAK to the IL-1 receptor complex
Wesche, H, et al (1997) Immunity, 7:837-47 (1997)
IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase
Li, Shyun, et al (2002) Proc Natl Acad Sci USA, 99:5567-72 (2002)
Species Reactivity Key Applications Host Format Antibody Type
H, M, R WB Rabbit Purified Monoclonal Antibody
Description:
Anti-IL-1R1 Antibody, rabbit monoclonal
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes a synthetic peptide encompassing residues near the N-terminus of human IL-1R type 1.
Molecular Weight:
80kDa
Immunogen:
KLH-conjugated synthetic peptide encompassing residues near the N-terminus of human IL-1R type 1.
Isotype:
IgG
Species Reactivity:
Human
Mouse
Rat
Quality Assurance:
Routinely evaluated by immunoblot.
Presentation:
100 μL of rabbit monoclonal IgG in 60% storage buffer (50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.
Storage Conditions:
2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.
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UniProt Number:
P14778
Entrez Gene Number:
NM_000877.2
Gene Symbol:
IL1R1
IL-1R-1
IL1R
P80
IL1RT1
IL1RA
IL-1R-alpha
CD121A
IL-1RT1
p80
D2S1473
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Entrez Gene Summary:
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.
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UniProt Summary:
FUNCTION: SwissProt: P14778 # Receptor for interleukin-1 alpha (IL-1A), beta (IL-1B), and interleukin-1 receptor antagonist protein (IL-1RA). Binding to the agonist leads to the activation of NF-kappa-B. Signaling involves formation of a ternary complex containing IL1RAP, TOLLIP, MYD88, and IRAK1 or IRAK2.
SIZE: 569 amino acids; 65402 Da
SUBUNIT: Binds IL1RAP.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
SIMILARITY: SwissProt: P14778 ## Belongs to the interleukin-1 receptor family. & Contains 3 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 TIR domain.
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Brand Family:
Upstate
Product Name:
Anti-IL-1R1 Antibod |