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Anti-phospho-Insulin Receptor (Tyr 1150/1151) Antibody, clone 10C3
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REFERENCES
Artemisia scoparia extract attenuates non-alcoholic fatty liver disease in diet-induced obesity mice by enhancing hepatic insulin and AMPK signaling independently of FGF21 pathway.
Wang, Zhong Q, et al. (2013) Metab. Clin. Exp., (2013)
Alpha 1,3-fucosyltransferase-VII regulates the signaling molecules of the insulin receptor pathway
Wang, Qiu-yan, et al (2007) FEBS J, 274:526-38 (2007)
Effects of hyperglycemia on the differential expression of insulin and insulin-like growth factor-I receptors in human normal peritoneal and adhesion fibroblasts
Rizk, Natalie N, et al (2006) Fertil Steril, 86 Suppl 4:1217-22 (2006)
Hybrid receptors formed by insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) have low insulin and high IGF-1 affinity irrespective of the IR splice variant
Slaaby, Rita, et al (2006) J Biol Chem, 281:25869-74 (2006)
Species Reactivity Key Applications Host Format Antibody Type
H EA, WB Mouse Purified Monoclonal Antibody
Description:
Anti-phospho-Insulin Receptor (Tyr 1150/1151) Antibody, clone 10C3
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes phosphorylated domain of Insulin receptor on Tyrosine 1150/1151.
Molecular Weight:
97 kDa
Immunogen:
KLH-conjugated synthetic peptide encompassing the surrounding amino acids of Tyrosine 1150/1151 on phosphorylated insulin receptor.
Modifications:
Phosphorylation
Clone:
10C3
Isotype:
IgG1
Species Reactivity:
Human
Control:
Includes pervanadate treated HEK293 lysate as a positive control
Quality Assurance:
Routinely evaluated by immunoblot.
Purification Method:
Thiophilic adsoption and size exclusion chromatography
Presentation:
In 1 mL of PBS containing 0.09% sodium azide, PEG, and sucrose and 50% glycerol.
Storage Conditions:
2 years at -20°C from date of shipment. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
UniProt Number:
P06213
Entrez Gene Number:
NM_000208.2
NM_001079817.1
Gene Symbol:
INSR
CD220
IR
HHF5
Alternate Names:
INSR
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Enzyme Assay
Western Blotting
Entrez Gene Summary:
After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene.
UniProt Summary:
FUNCTION: SwissProt: P06213 # This receptor binds insulin and has a tyrosine-protein kinase activity. Isoform Short has a higher affinity for insulin. Mediates the metabolic functions of insulin. Binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K). Can activate PI3K either directly by binding to the p85 regulatory subunit, or indirectly via IRS1.
SIZE: 1382 amino acids; 156307 Da
SUBUNIT: Tetram |