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Anti-19S regulator ATPase Antibody subunit S10b/Rpt4, clone p42-23
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REFERENCES
Distinct cellular and subcellular distributions of g protein-coupled receptor kinase and arrestin isoforms in the striatum.
Evgeny Bychkov,Lilia Zurkovsky,Mika B Garret,Mohamed R Ahmed,Eugenia V Gurevich (2012) PloS one.7
Subunit arrangement in the human 20S proteasome
Kopp, F, et al (1997) Proc Natl Acad Sci USA, 94:2939-44 (1997)
The 26S proteasome: subunits and functions
Tanaka, K and Tsurumi, C (1997) Mol Biol Rep, 24:3-11 (1997)
Species Reactivity Key Applications Host Format Antibody Type
H, M WB Mouse Purified Monoclonal Antibody
Description:
Anti-19S regulator ATPase Antibody subunit S10b/Rpt4, clone p42-23
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes 19S regulator ATPase subunit S10b/Rpt4.
Molecular Weight:
44 kDa
Immunogen:
Full length human recombinant Rpt4 protein.
Clone:
p42-23
Isotype:
IgG2a
Species Reactivity:
Human
Mouse
Presentation:
100 µL of purified immunoglobulin in PBS containing 0.01M sodium azide. Dilute to working strength with phosphate buffered saline pH 7.2-7.4.
Storage Conditions:
Stable for 1 year at -20°C from date of shipment for up to 12 months.
UniProt Number:
P62333
Entrez Gene Number:
NM_002806.2
Gene Symbol:
PSMC6
p42
P44
SUG2
CADP44
MGC12520
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Alternate Names:
p42; 26S proteasome ATPase subunit 6
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Entrez Gene Summary:
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12.
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UniProt Summary:
FUNCTION: SwissProt: P62333 # The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.
SIZE: 389 amino acids; 44173 Da
SUBUNIT: Found in the multi-protein complexes: the 26S proteasome (formed from the 20S proteasome and PA700), and the modulator. PA700 consists of 28 subunits arranged to form a cylinder-shaped complex by four stacked rings, each containing seven subunits. Interacts with PAAF1.
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity).
SIMILARITY: SwissProt: P6 |