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Anti-20S proteasome subunit α7 Antibody, clone MCP72
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REFERENCES
The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation
Meacham, G C, et al (2001) Nat Cell Biol, 3:100-5 (2001)
The infected cell protein 0 of herpes simplex virus 1 dynamically interacts with proteasomes, binds and activates the cdc34 E2 ubiquitin-conjugating enzyme, and possesses in vitro E3 ubiquitin ligase activity
Van Sant, C, et al (2001) Proc Natl Acad Sci USA, 98:8815-20 (2001)
The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins
Connell, P, et al (2001) Nat Cell Biol, 3:93-6 (2001)
Species Reactivity Key Applications Host Format Antibody Type
H, R, Rb, Yeast (S. cerevisiae) WB, IHC Mouse Purified Monoclonal Antibody
Description:
Anti-20S proteasome subunit α7 Antibody, clone MCP72
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes proteasome subunit alpha type 3.
Molecular Weight:
28 kDA
Immunogen:
Dinitrophenylated human placenta derived proteasomes.
Clone:
MCP72
Isotype:
IgG1
Species Reactivity:
Human
Rat
Rabbit
Yeast (S. cerevisiae)
Purification Method:
Ascites
Presentation:
100 µL of purified immunoglobulin from ascites in PBS containing 0.01M sodium azide. Dilute to working strength with phosphate buffered saline pH 7.2-7.4.
Storage Conditions:
Stable for 1 year at -20°C from date of shipment for up to 12 months.
UniProt Number:
P25788
Entrez Gene Number:
NM_002788.2
NM_152132.1
Gene Symbol:
PSMA3
HC8
MGC32631
PSC3
PSC8
MGC12306
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Alternate Names:
HC8; proteasome subunit alpha type 3
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Immunohistochemistry
Entrez Gene Summary:
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified.
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UniProt Summary:
FUNCTION: SwissProt: P25788 # The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
SIZE: 255 amino acids; 28433 Da
SUBUNIT: The proteasome is composed of at least 15 non identical subunits which form a highly ordered ring-shaped structure.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
SIMILARITY: SwissProt: P25788 ## Belongs to the peptidase T1A fam |