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Pseudosubstrate sequence from PKCα and ß. Highly specific inhibitor, which is N-terminal myristoylated to allow membrane permeability. IC50=8 µM for TPA activation of MARCKS phosphorylation in fibroblast primary cultures, and 98% inhibition at 100 µM. Partially reverses multidrug resistance in human breast cancer cells.
Product Specification
Alternative Name:PKC (20-28) (myristoylated)
Sequence:N-Myristoyl-Phe-Ala-Arg-Lys-Gly-Ala-Leu-Arg-Gln-OH
MW:1256.0
Formulation:TFA salt. Lyophilized.
Purity:≥98% (HPLC)
Solubility:Soluble in water or in 20mM TRIS-HCl, pH 7.5.
Long Term Storage:-20°C |