N-arachidonoyl phosphatidylethanolamine (NAPE) is a precursor in the biosynthesis of anandamide (AEA) via multiple pathways. NAPE can be cleaved by a phospholipase D leading to AEA and phosphatidic acid. Alternatively, in macrophages NAPE is cleaved by a phospholipase C leading to phosphoanandamide (pAEA). A phosphatase, PTPN22 is one enzyme that cleaves pAEA leading to the generation of anandamide. A third pathway proceeds via double deacylation of NAPE generating glycerophospho-NAE. Phosphodiesterase-mediated cleavage of this intermediate leads to anandamide. Product Specification Formula:C57H104NO9P MW:978.4 Purity:98% Long Term Storage:-20°C
