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TPEN
Heavy metal chelator
A cell permeable and extremely high-affinity chelator of heavy metals, yet with low affinity for Mg2+ and Ca2+. Lipid-soluble, crossing both natural and artificial membranes. TPEN can be used in conjunction with QUIN 2 (Prod. No. ALX-620-006) or QUIN 2/AM (Prod. No. ENZ-52012) to reduce heavy-metal quenching of QUIN 2 fluorescence in cells. Ion specificity: Zn2+>Fe2+>Mn2+>>Ca2+=Mg2+. Complex with Fe2+ catalyzes superoxide dismutation. Induces DNA fragmentation when chelated with Zn2+ and induces apoptosis in T cells.
Product Specification
Alternative Name: N,N,N',N'-Tetrakis-(2-pyridylmethyl)ethylenediamine
Formula: C26H28N6
MW: 424.6
CAS: 16858-02-9
Purity: ≥97%
Appearance: White to off-white solid.
Hazard: IRRITANT.
Solubility: Soluble in dimethyl formamide, DMSO, 100% ethanol or methanol.
Long Term Storage: +4°C |