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Nonactin
Macrotetrolide antibiotic. Monovalent cation ionophore with high selectivity for ammonium and potassium. Specifically inhibits the processing of cytoplasmic precursor proteins destined for the mitochondria. Inhibits the effects on P170 glycoprotein-mediated efflux of chemotherapeutic agents in multidrug resistant (MDR) cancer cells.
Product Specification
Alternative Name: Polynactin, Werramycin A
Formula: C40H64O12
MW: 736.9
Source: Isolated from Streptomyces griseus.
CAS: 6833-84-7
MI: 14: 6675
RTECS: RH1685000
Purity: ≥98% (TLC) (Total homologs)
Purity Detail: Mixture of 2 homologs (~95% nonactin and ~5% monactin).
Appearance: White to off-white solid.
Hazard: IRRITANT.
Solubility: Soluble in DMSO (10mg/ml), dichloromethane (10mg/ml), methanol, 100% ethanol; insoluble in water.
Long Term Storage: -20°C
Handling: Protect from moisture. |