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GYY 4137
H2S donor
Water-soluble, slow-releasing hydrogen sulfide (H2S) donor. Shows vasodilator and antihypertensive activity in rats in both acute (L-NAME-induced) or chronic (spontaneously hypertensive) hypertension models. Inhibits LPS-induced release of various proinflammatory mediators (such as IL-1β, IL-6, TNF-α, nitric oxide (NO) and PGE2) in RAW264.7 cells. Increases the synthesis of the anti-inflammatory chemokine IL-10 through NF-κB, ATF-2 and HSP27 dependent pathways in RAW264.7 cells.
Product Specification
Alternative Name: 4-Methoxyphenyl(morpholino)phosphinodithioate morpholinium salt
Formula: C11H15NO2PS2 . C4H10NO
MW: 288.3 . 88.1
Source: Synthetic.
CAS: 106740-09-4
Purity: ≥95%
Identity: Identity determined by 1H-NMR.
Appearance: White solid.
Solubility: Soluble in water (30mg/ml) or DMSO (15mg/ml).
Long Term Storage: -20°C
Handling: Protect from light and moisture.
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