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RITA
Inhibitor of p53/HDM2 interaction. Activator of p53 function in tumors. Potently inhibits the growth of a variety of cancer cell lines in the submicromolar range. It has been suggested that RITA selectively targets cells expressing p53 by other mechanisms than direct binding to the N-terminal domain of p53.
Product Specification
Alternative Name: Reactivation of p53 and Induction of Tumor Cell Apoptosis, 2,5-bis(5-Hydroxymethyl-2-thienyl)furan, NSC652287
Formula: C14H12O3S2
MW: 292.4
CAS: 213261-59-7
Purity: ≥98%
Appearance: White to brown crystalline solid.
Solubility: Soluble in 100% ethanol (1mg/ml), DMSO (20mg/ml), dimethyl formamide (30mg/ml); 0.5mg/ml soluble in a 1:1 solution of dimethyl formamide: PBS (pH 7.2) (dissolve RITA first in dimethyl formamide and then dilute with PBS).
Long Term Storage: -20°C
Use/Stability: Stable for at least two years after receipt when stored at -20°C. We do not recommend storing aqueous solutions for more than one day. |