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Locostatin
RKIP inhibitor
Cell permeable, potent inhibitor of interaction of Raf kinase inhibitor protein (RKIP) with Raf1 kinase. Blocks eukaryotic cell migration (IC50=14µM for inhibition of wound closure in MDCK cell monolayers). Inhibitor of early development in frog embryos and tissue dynamics in embryonic explants. Displays no antibacterial activity.
Product Specification
Alternative Name: UIC-1005, (4S)-3-[(E)-But-2-enoyl]-4-benzyl-2-oxazolidinone, (4S)-3-[(E)-1-Oxo-2-butenyl]-4-(phenylmethyl)-2-oxazolidinone
Formula: C14H15NO3
MW: 245.3
CAS: 133812-16-5
Purity: ≥95%
Identity: Identity determined by MS, 1H- and 13C-NMR.
Appearance: White to off-white solid.
Hazard: HARMFUL.
MAY BE MUTAGENIC.
Solubility: Soluble in DMSO (10mg/ml) or methanol (50mg/ml).
Long Term Storage: -20°C
Handling: Protect from light. |