IM-54

IM-54
Necrosis inhibitor
Cell permeable inhibitor of necrosis. Selectively blocks oxidative stress-induced necrotic cell death (~3µM IM-54 prevented ~50% cell death in HL60 cells exposed to 100µM H2O2). Does not protect against etoposide-induced apoptosis or display antioxidant properties. Does not affect S6K1 and PKC kinase activities at concentrations of 50µM.
Product Specification
Alternative Name: 2-(1H-Indol-3-yl)-3-pentylamino-maleimide
Formula: C19H23N3O2
MW: 325.4
CAS: 861891-50-1
Purity: ≥98% (HPLC)
Appearance: Yellow powder.
Solubility: Soluble in DMSO (100mg/ml), dichloromethane, 100% ethanol or methanol (10mg/ml).
Long Term Storage: -20°C
Handling: Protect from light.