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HA14-1
Bcl-2 ligand
Cell permeable, low molecular weight Bcl-2 ligand. Antagonizes the function of Bcl-2 and induces apoptosis. In HL-60 cells, HA4-1 (50µM and 4h incubation) induced apoptosis of more than 90% of the cells. Apoptosis is blocked by ZVAD-FM. IC50 = ~9µM for competition with Flu-BakBH3 binding to Bcl-2.
Product Specification
Alternative Name: Ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate
Formula: C17H17BrN2O5
MW: 409.2
CAS: 65673-63-4
Purity: ≥95% (1H-NMR)
Identity: Identity determined by IR, 1H-NMR.
Appearance: Off-white to light yellow powder.
Solubility: Soluble in DMSO (25mg/ml), dimethyl formamide or halogenated solvents; also soluble in 100% ethanol (25mg7ml, hot).
Long Term Storage: -20°C
Use/Stability: Unstable in solution. Prepare fresh solution for each application.
Handling: Keep cool and dry. |