A77 1726

A77 1726
Dihydrorotate dehydrogenase inhibitor
Physiologically active metabolite of the immunosuppressive drug leflunomide (Prod. No. ALX-430-095). Inhibits the activity of dihydrorotate dehydrogenase and of protein tyrosine kinases. Blocks TNF-mediated NF-κB activation in a dose- and time-dependent manner. Also inhibits the activity of cyclooxygenase-2 (COX-2) in vitro and in vivo.
Product Specification
Alternative Name: N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide, 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide
Formula: C12H9F3N2O2
MW: 270.2
CAS: 108605-62-5
Purity: ≥98% (HPLC)
Identity: Identity determined by NMR, IR and MS.
Appearance: White solid.
Solubility: Soluble in DMSO.
Long Term Storage: +4°C
Handling: Protect from light. Keep under inert gas.