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Leflunomide
Immunosuppressant
Immunosuppressive drug that inhibits T and B cell responses in vivo. Inhibitor of tyrosine phosphorylation (tyrosine kinase inhibitor), of dihydroorotate dehydrogenase, an enzyme for de novo pyrimidine synthesis, of TNF-dependent NF-κB activation, and of COX-2. The physiological activity of leflunomide is attributed mainly to its metabolite A77 1726 (Prod. No. ALX-430-096).
Product Specification
Alternative Name: HWA486, 5-Methylisoxazole-4-(4-trifluoromethylcarboxanilide), N-(4-Trifluoromethylphenyl)-5-methylisoxazol-4-carboxamide
Formula: C12H9F3N2O2
MW: 270.2
CAS: 75706-12-6
MI: 14: 5432
RTECS: NY2354200
Purity: ≥99% (HPLC)
Appearance: White to off-white solid.
Hazard: HARMFUL.
Solubility: Soluble in DMSO or methanol.
Long Term Storage: +4°C
Handling: Protect from light. Keep under inert gas.
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