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Zinc(II) Protoporphyrin IX
Heme oxygenase inhibitor
Potent and selective inhibitor of heme oxygenase (Ki=3nM), the enzyme that generates carbon monoxide (CO). Inhibits soluble guanylyl cyclase. Produces a time- and concentration-dependent inactivation of all three isoforms of nitric oxide synthase (IC50=0.8µM, 4.0µM, and 5.0µM for nNOS (NOS I), iNOS (NOS II) and eNOS (NOS III), respectively). Does not cross the blood-brain barrier. An useful tool to elucidate the role of CO in signal transduction and as a neurotransmitter.
Product Specification
Formula: C34H32N4O4Zn
MW: 626.0
CAS: 15442-64-5
Purity: ≥95% (TLC)
Identity: Identity determined by UV and NMR.
Appearance: Dark solid.
Solubility: Soluble in pyridine, dimethyl formamide or DMSO. Colloidal in aqueous base; slightly soluble in aqueous base/organic solvent mixtures.
Long Term Storage: -20°C
Use/Stability: Stable for at least 3 years after receipt when stored at -20°C. Make solutions fresh daily. Product may be unstable in solution if exposed to light.
Handling: Protect from light and moisture. |