|
MG-115
Proteasome inhibitor
Replaces Prod. #: BML-ZW8445
Potent, reversible proteasome inhibitor. Specifically inhibits the chymotrypsin-like activity of the proteasome. Has been shown to induce apoptosis in Rat-1 and PC12 cells via a p53-dependent pathway.The ubiquitin-proteasome system (UPS) and autophagy serve as two complementary, reciprocally regulated protein degradation systems, thus blockade of UPS by MG-115 activates autophagy.
Product Specification
Alternative Name: Z-LL-Nva-CHO, Z-Leu-Leu-Nva-CHO
Sequence: Z-Leu-Leu-Nva-CHO
Formula: C25H39N3O5
MW: 461.6
Purity: ≥95% (HPLC)
Appearance: White to off-white powder.
Solubility: Soluble in DMSO.
Long Term Storage: -20°C |