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Pepstatin A (synthetic)
Protease inhibitor
Replaces Prod. #: BML-PI120
Inhibitor of aspartate (acid) proteases, including pepsin, cathepsin D, renin, chymosin, bacterial aspartic proteinases and HIV proteases. Efficiently inhibits Fcγ receptor induction by IFN-γ. Blocks the endocytic pathway followed by an antibody when it enters the cell at the level of early endosomal compartments, resulting in inhibition of autoantigen presentation or viral transmission. Suppresses p-53-dependent apoptosis in lymphoid cells as well as TNFα-induced apoptosis in U937 cells. Inhibits degradation of autophagic cargo inside autophagolysosomes.
Product Specification
Alternative Name: Iva-Val-Val-Sta-Ala-Sta, i-Valeryl-L-Val-L-Val-AHMHA-L-Ala-AHMHA
Sequence: i-Valeryl-L-Val-L-Val-AHMHA-L-Ala-AHMHA
(AHMHA = (3S,4S)-4-Amino-3-hydroxy-6-methyl-heptanoic acid)
Formula: C34H63N5O9
MW: 685.9
Source: Synthetic.
CAS: 26305-03-3
MI: 14: 7147
RTECS: SC6155000
Purity: ≥98% (HPLC)
Appearance: White to off-white solid.
Solubility: Soluble in DMSO (5mg/ml), methanol (1mg/ml) or acetic acid.
Long Term Storage: -20°C
Use/Stability: Stable for at least 2 years after receipt when stored at -20°C.
Handling: Protect from light. |