Melittin (natural)

Melittin (natural)
PLA2 activator
Causes disruption of normal cellular activity and cell lysis. Binds calmodulin in a calcium-dependent manner. Activates phospholipase A2 (PLA2) and inhibits protein kinase C (PKC) by binding to the catalytic domain in a Mg-ATP sensitive manner. Antirheumatic.
Product Specification
Sequence: H-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2
Formula: C131H229N39O31
MW: 2846.5
Source: Isolated from bee venom.
CAS: 37231-28-0
MI: 14: 5824
RTECS: OS3960000
Purity: ≥85% (HPLC)
Purity Detail: Phospholipase A2 impurity: <5 units per mg solid.
Appearance: White to faint tan powder.
Hazard: HARMFUL.
Solubility: Soluble in PBS (5mg/ml) or water (5mg/ml).
Long Term Storage: -20°C
Handling: Very hygroscopic. Protect from light.