Human IL-10

IL-10, human recombinant
An anti-inflammatory cytokine
Product Overview
Alternate Names / Synonyms: Human IL-10, IL-10, IL10, IL 10, h-IL-10, rh-IL-10, recombinant human IL-10, recombinant IL-10, IL, interluekin
Gene Symbol: IL10
Accession #: P22301
Gene ID: 3586
Source: E. coli
Appearance: Lyophilized protein
Physical Form Description: Lyophilized from PBS
Molecular Weight: 19.6 kDa
Purity by SDS-PAGE: ≥98%
Purity by HPLC: ≥98%
Endotoxin Level: <0.1 ng/μg
Biological Activity: The ED₅₀ determined by the dose-dependent co-stimulation (with murine IL-4) of MC/9 cells is < 2 ng/ml, corresponding to a specific activity of > 5 x 10⁵ units/mg.
Reconstitution Instructions: Reconstitute in water a concentration of 0.1-1.0 µg/µl. The solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.
Storage Temp.: -20°C
Shipping: Gel pack
Background Information: IL-10 (Interleukin-10), originally known as Cytokine Synthesis Inhibitory Factor (CSIF), is an 18.6 kDa protein containing 161 amino acid residues. It shares over 80% sequence homology with the Epstein-Barr Virus protein BCRFI. The reported biological activities of IL-10 include inhibition of macrophage-mediated cytokine synthesis, suppression of the delayed-type hypersensitivity response, and stimulation of the Th2 cell response which results in elevated antibody production.
Handling: Centrifuge the vial prior to opening.