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Actinomycin D (10 mM)
Product Overview
Product Name: Actinomycin D (10 mM)
Alternate Name/Synonyms: Actinomycin C1, Actinomycin IV, Dactinomycin
Description: An antineoplastic antibiotic. Inhibits DNA-primed RNA polymerase by complexing with DNA via deoxyguanosine residues. A DNA-intercalator with growth inhibitory activity against certain leukemias and sarcomas. At higher concentrations, DNA polymerase is inhibited. Inhibits cell growth and colony formation in synchronized HeLa cells. A potent inducer of apoptosis in many cell lines (1).
Peptide Sequence: N/A
Appearance: Liquid
Formulation: In DMSO (10 mM)
CAS Number: 50-76-0
Molecular Formula: C₆₂H₈₆N₁₂O₁₆
Molecular Weight: 1255.5
Purity: >98% by TLC
Solubility:N/A
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from light and moisture
SMILES: CC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O) C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O) C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)N)C
InChi: InChI=1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)
InChi Key: RJURFGZVJUQBHK-UHFFFAOYSA-N
PubChem CID: 2019
MDL Number: MFCD00005033
USAGE: For Research Use Only! Not For Use in Humans. |