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产品说明：
Synonyms L-NG-Nitroarginine methyl ester
Formal Name N5-[imino(nitroamino)methyl]-L-ornithine, methyl ester, monohydrochloride
CAS Number 51298-62-5
Molecular Formula C7H15N5O4 · HCl
Formula Weight 269.7
Formulation A crystalline solid
Purity ≥99%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
描述：
L-NAME requires hydrolysis of the methyl ester by cellular esterases to become a fully functional inhibitor (L-NNA). L-NNA exhibits some selectivity for inhibition of neuronal and endothelial isoforms. It exhibits Ki values of 15 nM, 39 nM, and 4.4 µM for nNOS (bovine), eNOS (human), and iNOS (mouse), respectively.The reported Ki value for the inhibition of iNOS ranges from 4-65 µM. L-NAME inhibits cGMP formation in endothelial cells with an IC50 of 3.1 µM (in the presence of 30 µM arginine) and reverses the vasodilation effects of acetylcholine in rat aorta rings with an EC50 of 0.54 µM. |