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产品说明：
Synonyms BRL 49653
Formal Name 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione
CAS Number 122320-73-4
Molecular Formula C18H19N3O3S
Formula Weight 357.4
Formulation A crystalline solid
Purity ≥98%
λmax 248, 311 nm
Stability 2 years
Storage -20°C
描述：
Thiazolidinediones (TZDs) are a group of structurally related peroxisome proliferator-activated receptor γ (PPARγ) agonists with antidiabetic actions in vivo.1↗,2↗ Rosiglitazone (BRL 49653) is a prototypical TZD and has served as a reference compound for this class.3↗ Rosiglitazone is a potent and selective PPARγ ligand. It binds to the PPARγ ligand-binding domain with a Kd of 43 nM.3↗ It activates luciferase-based expression constructs PPARγ1 and PPARγ2 with EC50 values of approximately 30 nM and 100 nM, respectively.3↗ Rosiglitazone is active in vivo as an antidiabetic agent in the ob/ob mouse model, and has been used as an oral hypoglycemic agent in the treatment of Type II diabetes in humans for many years. |