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IGFBP5 Blocking Peptide
Cayman Chemical Item Number 10008206
Description
IGFBP5 is a secreted protein that is a critical member of the IGF axis. It binds IGF-1 and restricts it from accessing its cell-surface receptor (IGF-1R). This aids in regulation of cell growth, differentiation, and apoptosis.1↗ IGFBP5 also displays IGF-1 independent transactivational activity in the nucleus.2↗ Some tissues and cell types with higher levels of this protein include kidney, heart, placenta, and skeletal cells.3↗ Expression has also been reported in a variety of cancers, including mammary gland and neuroblastoma.1↗,4↗ IGFBP5 (272 amino acids) has a calculated molecular weight of 30.6 kDa. Reported glycosylation and phosphorylation sites may explain the band migration to 33 kDa.1↗,5↗ Cayman’s IGFBP5 polyclonal antibody is directed against a synthetic peptide sequence that partially overlaps the IGFBP5 region identified as a nuclear localization signal.2↗
Synonyms
Insulin-Like Growth Factor-Binding Protein 5 Blocking Peptide
IBP-5 Blocking Peptide
IGF-Binding Protein 5 Blocking Peptide
Formal Name 200 µg peptide in 200 µl TBS, pH 7.4, containing 0.1% BSA and 0.02% sodium azide
Formulation 200 µg of peptide in 200 µl of TBS, pH 7.4, containing 0.1% BSA and 0.02% sodium azide
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere |