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JNJ-10198409
Cayman Chemical Item Number 10008131
Description
Inhibition of the tyrosine kinase activity of growth factor receptors such as the platelet-derived growth factor (PDGF-BB) receptor can have potent antiangiogenic and antiproliferative activity.1↗ JNJ-10198409 is a small molecule inhibitor of PDGF-BB tyrosine kinase with an IC50 value of 4.2 nM when tested in human coronary artery smooth muscle cells.2↗ JNJ-10198409 is a competitive antagonist of the ATP binding and hydrolysis at this receptor, resulting in a dose dependent inhibition of tumor growth and angiogenesis.
Formal Name N-(3-fluorophenyl)-2,4-dihydro-6,7-dimethoxy-indeno[1,2-c]pyrazol-3-amine
CAS Number 627512-69-0
Molecular Formula C18H16FN3O2
Formula Weight 325.3
Formulation A crystalline solid
Purity ≥98%
λmax 267, 302 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES COc1cc2c(Cc3c(n[nH]c23)Nc2cccc(F)c2)cc1OC
InCHI Code 1S/C18H16FN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22)
InCHI Key ZDNURMVOKAERHZ-UHFFFAOYSA-N |