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SPD-304Exclusive
Cayman Chemical Item Number 10008012
Description
Tumor necrosis factor α (TNFα) is a primary mediator of many inflammatory conditions including rheumatoid arthritis, toxic shock, and sepsis.1↗,2↗,3↗ TNFα functions as a trimer and promotes receptor trimerization to activate proinflammatory and/or apoptotic signalling pathways. 4↗,5↗ SPD-304 is an inhibitor of TNFα that prevents binding to the TNF Receptor 1 (TNFR1) with an IC50 of 22 µM.6↗ It binds to the biologically active TNFα trimer and promotes accelerated displacement of a single subunit to rapidly inactivate the cytokine. In a cell based assay, SPD-304 inhibited TNFα-mediated stimulation of IKB degradation with an IC50 of 4.6 µM.6↗
Formal Name 6,7-dimethyl-3-[[methyl[2-[methyl[[1-[3-(trifluoromethyl)phenyl]-1H-indol-3-yl]methyl]amino]ethyl]amino]methyl]-4H-1-benzopyran-4-one
CAS Number 869998-49-2
Molecular Formula C32H32F3N3O2
Formula Weight 547.6
Formulation A crystalline solid
Purity ≥98%
λmax 209, 252, 299 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES CN(CCN(C)Cc1cn(c2cccc(c2)C(F)(F)F)c2ccccc12)Cc1coc2cc(C)c(C)cc2c1=O
InCHI Code 1S/C32H32F3N3O2/c1-21-14-28-30(15-22(21)2)40-20-24(31(28)39)18-37(4)13-12-36(3)17-23-19-38(29-11-6-5-10-27(23)29)26-9-7-8-25(16-26)32(33,34)35/h5-11,14-16,19-20H,12-13,17-18H2,1-4H3
InCHI Key JZNXLPPJRFFECJ-UHFFFAOYSA-N |