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Arachidonoyl-1-thio-GlycerolExclusive
Cayman Chemical Item Number 10007904
Description
2-Arachidonoyl glycerol (2-AG) is an endogenous agonist of the central cannabinoid (CB1) receptor.1↗,2↗ It is present at relatively high levels in the central nervous system and is the most abundant molecular species of monoacylglycerol found in rat brain.2↗,3↗ Monoacylglycerol lipase (MGL) hydrolyzes 2-AG to arachidonic acid and glycerol, thereby terminating its biological actions.4↗ Arachidonoyl-1-thio-glycerol is a thioester substrate analog of 2-AG that can be utilized for the measurement of MGL activity.5↗ Hydrolysis of the thioester bond by MGL generates a free thiol that reacts rapidly with the chromogenic reagent DTNB (Ellman’s reagent) resulting a yellow product with an absorbance maximum at 412 nm.
Synonyms 1-S-Arachidonoyl-1-mercapto-2,3-propanediol
Formal Name 5Z,8Z,11Z,14Z-eicosatetraenyl,1-thio glycerol
CAS Number 1309664-54-7
Molecular Formula C23H38O3S
Formula Weight 394.6
Formulation A solution in acetonitrile
Purity ≥95%
λmax 233 nm
Stability 6 months
Storage -80°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)SCC(O)CO
InCHI Code 1S/C23H38O3S/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23(26)27-21-22(25)20-24/h6-7,9-10,12-13,15-16,22,24-25H,2-5,8,11,14,17-21H2,1H3/b7-6-,10-9-,13-12-,16-15-
InCHI Key UUOPRYPOAXYNLX-DOFZRALJSA-N |