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Oleoyl Ethanolamide-d2
Cayman Chemical Item Number 10007823
Description
Oleoyl ethanolamide-d2 (OEA-d2) contains two deuterium atoms at the 11 position. It is intended for use as an internal standard for the quantification of OEA by GC- or LC-mass spectrometry. OEA is an analogue of the endocannabinoid arachidonoyl ethanolamide (AEA) found in brain tissue and in chocolate.1↗ It is one of the long chain fatty acid ethanolamides that accumulates rapidly in infarcted tissue,2↗ but its biosynthesis is reduced in the intestine of rats following food deprivation.3↗ OEA is an endogenous, potent agonist for peroxisome proliferator-activated receptor α (PPARα), exhibiting an EC50 value of 120 nM in a transactivation assay.4↗ Systemic administration of OEA suppresses food intake and reduces weight gain in rats (10 mg/kg intraperitoneally) and PPARα wild-type mice, but not in PPARα knockout mice.3↗,4↗ These data indicate that OEA regulates food intake by a PPARα-mediated mechanism.
Synonyms Oleic Acid Ethanolamide-d2 OEA-d2
Formal Name N-(2-hydroxyethyl)-9Z-octadecenamide-11,11-d2
CAS Number 1245477-09-1
Molecular Formula C20H37D2NO2
Formula Weight 327.5
Formulation A solution in ethanol
Purity ≥99% deuterated forms (d1-d2)
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES CCCCCCCC([2H])([2H])/C=C\CCCCCCCC(N([H])CCO)=O
InCHI Code 1S/C20H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)21-18-19-22/h9-10,22H,2-8,11-19H2,1H3,(H,21,23)/b10-9-/i8D2
InCHI Key BOWVQLFMWHZBEF-MSKGDGSWSA-N |